Diabetes Support

Why people with diabetes may be at increased risk of Vitamin B deficiency

  • Certain tablets/capsules used to treat diabetes can lower Vitamin B12 levels and cause symptoms of Vitamin B12 deficiency 2
  • 1 in 2 people with diabetes may develop peripheral neuropathy (pins-and-needles, numbness, weakness of hands and feet) 1
  • People with diabetes may be at increased risk of Vitamin B1, B6, B12 deficiencies (these vitamins are all important for normal nerve function) 1

What are the benefits of Vitamin B1, B6 and B12?

All three of these B Vitamins help the body to convert the carbohydrates, protein and fats in food into energy that can be used by the body.3,4 They are also important for the maintenance of healthy nerve tissue.3 Other functions include:


Vitamin B1 – maintenance of healthy muscle tissue4


Vitamin B6 – formation of haemoglobin (substance in red blood cells that transports oxygen around the body) and maintenance of healthy skin 3,4


Vitamin B12 – formation of red blood cells and DNA (genetic material of cells) 3,4

Symptom checker*

If you have any of the following symptoms, you may have a Vitamin B deficiency. *2,4-6


What is Neurobion®?

Neurobion® is South Africa’s number 1 Vitamin B treatment.7
Neurobion® Tablets are indicated where a deficiency of the relevant vitamins exist. Neurobion® Tablets contain three B Vitamins:
• 100 mg Vitamin B1 (thiamine)
• 200 mg Vitamin B6 (pyridoxine)
• 200 μg Vitamin B12 (cobalamin)

You may need to take Neurobion® for as long as you are at risk of Vitamin B deficiency.2

How do you take Neurobion® tablets?

Dosage (30’s)

1 tablet daily


References – Further Reading: 1.Tong HI. Influence of Neurotropic Vitamins on the Nerve Conduction Velocity in Diabetic Neuropathy. Ann Acad Med 1980; 9(1):65-70. 2. da Silva L, McCray S. Vitamin B12: No One Should Be Without It. Pract Gastroenterol 2009:34-46. 3. NHS Choices. Vitamins and minerals – B vitamins and folic acid. [Online] 2012 Nov 26 [cited 2014 Sept 10]. Available from: URL: http://www.nhs.uk/Conditions/vitamins-minerals/Pages/Vitamin-B.aspx. 4. Disorders of Nutrition and Metabolism. Section 11. In: The Merck Manual of Medical Information. Second Edition. (eds) Beers SL, Bowman MA. Pocket Books, New York, London, Toronto, Sydney. Pp 918-926. 5. Merck Manual. Thiamine. [Online] 2012 Dec [cited 2014 Aug 6]. Available from: URL: http://goo.gl/wkomZy. 6. Frye RE, Griffing GT. Pyridoxine Deficiency Clinical Presentation. Medscape [Online] 2014 Jan 15 [cited 2014 Aug 6]. Available from: URL: http://emedicine.medscape.com/article/124947-clinical. 7. IMS TPM. January 2016. IMS South Africa.

For full prescribing information refer to the package insert approved by the Medicine Regulatory Authority

SCHEDULE-1 Neurobion® Tablets. Each tablet contains Vitamin B1 100 mg, Vitamin B6 200 mg and Vitamin B12 200 µg. Reg. No.: H2487 (Act 101/1965). Applicant: Merck (Pty) Ltd. Reg. No.: 1970/004059/07. 1 Friesland Drive, Longmeadow Business Estate South, Modderfontein, South Africa, 1645. Tel: +27 (0) 11 372 5000 / Fax: +27 (0) 11 372 5252. Report adverse events to drug.safety.southeastafrica@merckgroup.com or +27 (0) 11 608 2588 (Fax Line). ZA.NEU.15.10.006 March 2016.

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