The gold standard in joint care


As we get older our joints are affected by changes in cartilage and in connective tissue which result in joints becoming stiffer and less flexible.

Where do degenerative changes occur?

Chondroitin sulfates are large molecule-sized compounds of glycosaminoglycans and disaccharide polymers that are used in the formation of the structure of the joint matrix. The joint matrix is the intercellular substance of cartilage which consists of extracellular fibres and ground substance or fluid.

Chondroiton can assist as follows:

  • Chondroitin is hydrophilic, meaning that it pulls towards itself, and can therefore help to attract water molecules into the cartilage matrix, which also acts as a spongy shock absorber.
  • Since chondroiton is a building block of the protoglycan molecules found in cartilaginous tissues of most mammals, chondroitin sulphates can influence the formation of new cartilage matrix by stimulating chondrocyte metabolism and synthesis of collagen and proteoglycan.
  • Chondroiton sulfates have also been reported as an inhibitor of the enzyme leukocyte elastase, which is secreted during the inflammatory response, and hyaluronidase, an enzyme that lowers the viscosity of the fluid between the cells in the joint.

Chondroiton sulfates can also stimulate the production of hyaluronic acid by synovial cells. Hyaluronic acid is a compotent of the synovial fluid between the joints and is responsible for lubricating the joint. Viscosity is subsequently improved and synovial fluid levels return to normal.


How can Chondroitin & Glucosamine assist the body?

Healthy cartilage requires three things:

  • Water for lubrication and nourishment,
  • Proteoglycans to attract and hold the water
  • And collagen “netting” to keep the proteoglycans in place

Chondroitin sulfate and glucosamine sulfate are key structural components in cartilage that play an important role in the maintenance of joints.

They work together to help the body to build and repair damaged or eroded cartilage and inflamed joints. International research has shown that, in combination, chondroitin and glucosamine can assist the body to counter impaired mobility, inflammation and therefore pain.


Glucosamine sulfate is an amino-monosaccharide that is naturally produced in humans and can assist as follows:

  • Glucosamine is one of the major substrates used in the biosynthesis of large molecules that form articular cartilage which covers the articular surface of bones. Articular surfaces are parts of bone that connect with other bones in a joint.
  • These larger molecules include glycosaminoglycans, proteoglycans and hyaluronic acid. Therefore, glucosamine is a major building block of proteoglycans and is needed to make the proteins that bind water in the joints.


The gold standard in joint care


As we get older our joints are affected by changes in cartilage and in connective tissue which result in joints becoming stiffer and less flexible.

What can we do to assist our bodies to keep our joints healthy?

  • Degenerative changes commonly occur in hip and knee joints when they begin to lose joint cartilage.
  • Finger joints loose cartilage and the bones thicken slightly. Finger joints are more common in women and may be genetically transformed from generation to generation.
  • Some joints, such as the ankle, typically change very little with aging.
  • Between each bone in the spine (vertebrae) is a gel-like cushion (called a disk). As we age the disks gradually lose fluid and become thinner causing the middle of the body (trunk) of the disk to become shorter. In addition, the bones or vertebrae lose some of their mineral content, making each bone thinner. The spinal column becomes curved and compressed or backed together.

How can Chondroitin & Glucosamine assist the body?

Taking a supplement containing glucosamine and chondritin can help to keep our joints healthy. We can also support our joints by:

  • Keeping our weight within a healthy range as a healthy weight limits the amount of stress placed on our joints.
  • Trying to low impact exercises that do not put too much pressure on our joints. This builds muscles which, in turn, supports joints. Cycling and/or swimming are good examples. It is important to consult with a healthcare provider before beginning a new exercise program.
  • Drink enough water. Joints, as well as every other cell in our body, need adequate amounts of water to function optimally.

For further information visit our website: www.osteoeze.co.za

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