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Hypertension Medication Supplement

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Overcoming side effects of high blood pressure medication

High blood pressure (hypertension) is a serious chronic disease that increases the risk for heart disease and stroke. A class of medication, known as an ACE inhibitor, is used in the treatment of high blood pressure.1, 4, 6

Essential nutrients may however be depleted as a result of high blood pressure and the treatment thereof by means of ACE inhibitors.1, 5

The Solution

ACEI-GAP provides a solution for supplementing these essential nutrients, with just one capsule per day.1

Vitamin D and Zinc are two very important role players in cardiovascular health, and both these two essential nutrients are at risk for depletion though high blood pressure and the treatment thereof.2, 3, 5

Zinc is essential for the functioning of numerous enzymes, including those involved in keeping the cardiovascular system in good health.3, 7

Over and above bone and calcium metabolism, vitamin D (particularly vitamin D3) is recognised as important for cardiovascular health and its deficiency as a potential risk factor for several cardiovascular disease processes.2, 7

ACEI-GAP contains vitamin D3 and Zinc that should be taken by each patient suffering from high blood pressure and taking medication for it.1, 2, 3

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A serious chronic disease with a 67 % increase between 1990 and 20101*

Almost 8 in 10 South Africans ≥ 50 years of age have hypertension, considered the highest incidence ever reported by a nationally representative survey3*

cause of natural death in South Africans ≥ 65 years after diabetes (#1) and cerebrovascular disease (#2)4

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Impact of ACEIs

Impact of ACEIs on vitamin D & zinc status

of deaths overall are caused by high blood pressure1

of deaths in people with diabetes is caused by high blood pressure1

of heart disease, stroke and heart failure is caused by high blood pressure1

Mortality reduction should be the ultimate goal of antihypertensive treatment5

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Mortality Reduction

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Role of vitamin D and zinc in RAS & normal BP control

Renin Angiotensin System (RAS)7

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Dosage & directions for use

Take one (1) capsule daily2

ACEI-GAP. Each capsule contains Vitamin D3 800 IU; Zinc 15 mg. For full prescribing information refer to the package insert. 201809121097800
Health Supplement. This unregistered medicine has not been evaluated by the SAHPRA for its quality, safety or intended use.

Adcock Ingram Limited. Reg. No. 1949/034385/06. Private Bag X69, Bryanston, 2021, South Africa. Tel. +27 11 635 0000 www.adcock.com

Medical References

Introduction references: ACEI-GAP approved package insert, 2017, Adcock Ingram Reddy Vanga, Role of Vitamin D in cardiovascular health, Americal Journal of Cardiology, Sep 15, 2010, 106(6):798-80 Little PJ, Zinc and cardiovascular disease, Nutrition Journal, Nov, 2010 GUMS JG, Use of ACE inhibitors in the treatment of cardiovascular disease, American Pharmacy Journal, 1992 Jun; (6):62-70 Genevie Kocourek, Nutrient depletion from medications: What should you know?, Trinity Intergrative Family Medicine, June 11, 2016 Richard E. Klabunde, PhD, Angiotensin Converting Enzyme (ACE) Inhibitors, Cardiovascular Pharmacology Concepts, Nov 17, 2017 Amy Myszko, What Are the Benefits of Vitamin D3, Magnesium & Zinc?, Livestrong, Aug 14, 2017 Further references: 1. Hypertension in Sub-Saharan Africa. Why prevention and control are important. A fact sheet from the World Hypertension League and the International Society of Hypertension. [cited 2017 Mar 17]; Available from: http://www.worldhypertensionleague.org/images/HTN_Infographic_Professionals_2015.pdf. 2. ACEI-GAP approved package insert, 2017. 3. Lloyd-Sherlock P, Beard J, Minicuci N, et al. Hypertension among older adults in low and middle-income countries: prevalence, awareness and control. Int J Epidemiol 2014;43:116-128. 4. Lehohla PJ. Mortality and causes of death in South Africa, 2015: findings from death notification. STATS SA statistical release P0309.3. [cited 2017 March 17]; Available from: http://www.statssa.gov.za/?page_id=1854&PPN=P0309.3&SCH=6987. 5. Ferrari R, Boersma E. The impact of ACE inhibition on all-cause and cardiovascular mortality in contemporary hypertension trials: a review. Expert Rev Cardiovasc Ther 2013;11(6):705–717. 6. Seedat YK, Rayner BL, Veriava Y. South African hypertension practice guideline 2014. Cardiovasc J Afr 2014;25(6):288-294. 7. Chun Li Y, Qiao G, Uskokovic M, et al. Vitamin D: a negative endocrine regulator of the renin-angiotensin system and blood pressure. J Steroid Biochem Molec Biol 2004;89-90:387-392. 8. Cohen N, Golik A. Zinc balance and medications commonly used in the management of heart failure. Heart Fail Rev 2006;11:19-24. 9. Sohl E, van Schoor NM, de Jongh RT, et al. The impact of medication on vitamin D status in older individuals. Eur J Endocrinol 2012;166:477-485. 10. Ferder M, Inserra F, Manucha W. The world pandemic of vitamin D deficiency could possibly be explained by cellular inflammatory response activity induced by the renin-angiotensin system. Am J Physiol Cell Physiol 2013;304:C1027-C1039. 11. Mchiza ZJ, Steyn NP, Hill J, et al. A review of dietary surveys in the adult South African population from 2000 to 2015. Nutrients 2015;7:8227-825. 12. Braun LA, Rosenfeld F. Pharmaco-nutrient interactions – a systemic review of zinc and antihypertensive therapy. Int J Cain Pract 2013;67(8):717-725. 13. Golik A, Zaidenstein R, Dishi V et al. Effects of captopril and enalapril on zinc metabolism in hypertensive patients. J Am Coll Nutri 1998;17(1):75-78. 14. Ross CA, Taylor CL, Yaktine AL, et al (eds). Dietary Reference Intakes (DRIs): Dietary reference intakes for calcium and vitamin D. Institute of Medicine, National Academy of Sciences, 2011. [cited 2017 Mar 17]; Available from:from: https://www.nap.edu/13050. 15. Zinc – health professional fact sheet. NIH Office of Dietary Supplements, 2016. [cited 2017 Mar 17]; Available from: https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/

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